Pub. Date : 2022 Jan
PMID : 34875483
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Combination of CTLA-4 blockade with MUC1 mRNA nanovaccine induces enhanced anti-tumor CTL activity by modulating tumor microenvironment of triple negative breast cancer. | nanovaccine | mucin 1, cell surface associated | Homo sapiens |
| 2 | We have previously reported that combination of anti-CTLA-4 antibody with MUC1 mRNA nanovaccine may mutually enhance each single treatment. | nanovaccine | mucin 1, cell surface associated | Homo sapiens |
| 3 | But the enhancement mechanism of therapeutic efficacy of MUC1 mRNA nanovaccine plus anti-CTLA-4 monoclonal antibody (mAb) is unknown. | nanovaccine | mucin 1, cell surface associated | Homo sapiens |
| 4 | In this study, anti-tumor CTL activity induced by combination of CTLA-4 Blockade with MUC1 mRNA nanovaccine and immunosuppressive factors in the TME of triple negative breast cancer were investigated. | nanovaccine | mucin 1, cell surface associated | Homo sapiens |
| 5 | Therefore, it can be concluded that combination of CTLA-4 blockade with MUC1 mRNA nanovaccine enhances anti-tumor cytotoxic T-lymphocyte activity by reducing immunosuppressive TME and inhibiting tumor-promoting STAT3 signaling pathway. | nanovaccine | mucin 1, cell surface associated | Homo sapiens |