Title : Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

Pub. Date : 1986 Jun 1

PMID : 3486936






2 Functional Relationships(s)
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1 On a weight basis (1 microgram/kg) rTNF alpha and rIL-1 produce the same amount of fever and induce comparable levels of PGE2 in rabbit hypothalamic cells in vitro; like IL-1, TNF fever is blocked by drugs that inhibit cyclooxygenase. Dinoprostone interleukin 1 complex Mus musculus
2 These studies show that TNF (cachectin) is another endogenous pyrogen which, like IL-1 and IFN-alpha, directly stimulate hypothalamic PGE2 synthesis. Dinoprostone interleukin 1 complex Mus musculus