Title : In vitro ion channel profile and ex vivo cardiac electrophysiology properties of the R(-) and S(+) enantiomers of hydroxychloroquine.

Pub. Date : 2022 Jan 15

PMID : 34863995






2 Functional Relationships(s)
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1 We found that R(-)HCQ and S(+)HCQ block human Kir2.1 and hERG potassium channels in the 1 muM-100 muM range with a 2-4 fold enantiomeric separation. Hydroxychloroquine ETS transcription factor ERG Homo sapiens
2 We found that R(-)HCQ and S(+)HCQ block human Kir2.1 and hERG potassium channels in the 1 muM-100 muM range with a 2-4 fold enantiomeric separation. Hydroxychloroquine ETS transcription factor ERG Homo sapiens