Pub. Date : 2022 Jan
PMID : 34863716
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Irisin rescues diabetic cardiac microvascular injury via ERK1/2/Nrf2/HO-1 mediated inhibition of oxidative stress. | irisin | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 2 | Irisin stimulated the phosphorylation of extracellular regulated protein kinases (ERK) 1/2 and nuclear factor erythroid-derived 2-like 2 (Nrf2) nuclear translocation, while U0126 (the inhibitor of ERK1/2) inhibited irisin-induced Nrf2 nuclear translocation and HO-1 expression. | irisin | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 3 | Irisin stimulated the phosphorylation of extracellular regulated protein kinases (ERK) 1/2 and nuclear factor erythroid-derived 2-like 2 (Nrf2) nuclear translocation, while U0126 (the inhibitor of ERK1/2) inhibited irisin-induced Nrf2 nuclear translocation and HO-1 expression. | irisin | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 4 | Irisin stimulated the phosphorylation of extracellular regulated protein kinases (ERK) 1/2 and nuclear factor erythroid-derived 2-like 2 (Nrf2) nuclear translocation, while U0126 (the inhibitor of ERK1/2) inhibited irisin-induced Nrf2 nuclear translocation and HO-1 expression. | irisin | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 5 | Nrf2 siRNA inhibited irisin"s antioxidative effects. | irisin | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 6 | CONCLUSION: Irisin could rescue cardiac microvessels against oxidative stress and apoptosis in diabetes via ERK1/2/Nrf2/HO-1 pathway. | irisin | nuclear factor, erythroid derived 2, like 2 | Mus musculus |