Pub. Date : 2021
PMID : 34858188
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Farrerol Ameliorated Cisplatin-Induced Chronic Kidney Disease Through Mitophagy Induction via Nrf2/PINK1 Pathway. | farrerol | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 2 | Previously, Our study has showed that farrerol can activate Nrf2 and ameliorate cisplatin-induced acute kidney injury (AKI). | farrerol | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 3 | In this study, we evaluated the correlation between mitophagy and the protective effect of the Nrf2 activator farrerol on cisplatin-induced CKD by using C57BL/6 wild-type and Nrf2 knockout mice. | farrerol | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 4 | Similar to previous results, farrerol activated Nrf2 on the 38th day of cisplatin administration, subsequently stimulating the Nrf2-targeted antioxidant enzymes HO-1 and NQO1. | farrerol | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 5 | Similar to previous results, farrerol activated Nrf2 on the 38th day of cisplatin administration, subsequently stimulating the Nrf2-targeted antioxidant enzymes HO-1 and NQO1. | farrerol | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 6 | These data indicated that farrerol effectively inhibited cisplatin-induced inflammation and renal fibrosis by activating Nrf2 and PINK1/Parkin-mediated mitophagy, which provides a potential novel therapeutic target for CKD. | farrerol | nuclear factor, erythroid derived 2, like 2 | Mus musculus |