Title : The Effects of Folic Acid Supplementation on Pro-inflammatory Mediators: a Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.

Pub. Date : 2021 Dec

PMID : 34857394






2 Functional Relationships(s)
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1 Folic acid supplementation significantly reduced serum levels of C-reactive protein (mean difference (MD), -0.21 mg/L; 95% CI, -0.41 to -0.01; n = 16), TNF-alpha (MD, -14.88 pg/mL; 95% CI, -23.68 to -6.09; n = 10), and IL-6 (MD, -0.93 pg/mL; 95% CI, -1.72 to -0.14; n = 11). Folic Acid tumor necrosis factor Homo sapiens
2 A significant nonlinear association was also found between folic acid dosage (Pnonlinearity <0.001) and duration of administration (Pnonlinearity <0.001) with serum TNF-alpha levels. Folic Acid tumor necrosis factor Homo sapiens