Title : Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast.

Pub. Date : 2021 Aug 26

PMID : 34849907






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using human cell culture, molecular modeling, and humanized yeast, we find that TBZ selectively targets only 1 of 9 human beta-tubulin isotypes (TUBB8) to specifically disrupt endothelial cell microtubules. Thiabendazole tubulin beta 8 class VIII Homo sapiens