Pub. Date : 2021 Dec 1
PMID : 34847866
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | pERK-mediated IL8 secretion can enhance the migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells. | Cisplatin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | We hypothesized that IL8 might regulate migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells through the ERK pathway. | Cisplatin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | IL8 secreted by CD10H HN6 promoted migration and invasion and restored tumor chemosensitivity via the p-ERK signaling pathway, while the inhibition of IL8 increased the chemosensitivity to cisplatin. | Cisplatin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | IL8 secreted by CD10H HN6 promoted migration and invasion and restored tumor chemosensitivity via the p-ERK signaling pathway, while the inhibition of IL8 increased the chemosensitivity to cisplatin. | Cisplatin | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | CONCLUSIONS: IL8 secretion by CD10 positive cells promotes migration, invasion, and cisplatin resistance of OSCC via the p-ERK signaling pathway. | Cisplatin | C-X-C motif chemokine ligand 8 | Homo sapiens |