Title : IL-33, IL-37, and Vitamin D Interaction Mediate Immunomodulation of Inflammation in Degenerating Cartilage.

Pub. Date : 2021 Oct 26

PMID : 34842603






2 Functional Relationships(s)
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1 The results of this study revealed that vitamin D deficiency is associated with an increased expression of IL-33, IL-37, IL-6, TNF-alpha, TLRs, DAMPs, and MMPs, while vitamin D supplementation is associated with a decreased expression of the former. Vitamin D tumor necrosis factor Homo sapiens
2 Taken together, the results of this study suggest that modulating expression of IL-33, IL-6, TNF-alpha, TLRs, DAMPs, and MMPs with vitamin D supplementation may serve as a novel therapeutic to attenuate inflammation and cartilage degeneration in osteoarthritis. Vitamin D tumor necrosis factor Homo sapiens