Title : Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation.

Pub. Date : 2022 Jun

PMID : 34837219






2 Functional Relationships(s)
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1 KEY RESULTS: Chloroquine and hydroxychloroquine blocked hERG with IC50 of 1.47+-0.07 muM and 3.78+-0.17 muM respectively, indicating proarrhythmic risk at concentrations effective against SARS-CoV-2 in vitro. Hydroxychloroquine ETS transcription factor ERG Homo sapiens
2 Acidosis significantly reduced potency of all drugs, whereas increased temperature decreased potency of chloroquine and hydroxychloroquine against hERG but increased potency for azithromycin. Hydroxychloroquine ETS transcription factor ERG Homo sapiens