Pub. Date : 2021 Nov 11
PMID : 34830081
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Neuroprotective effects of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors-statins-via both cholesterol-dependent and independent mechanisms have been shown in animal and cell culture models. | Cholesterol | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 2 | We present possible statin effects on PD under the hypothesis that they may depend on the HMG-CoA reductase gene (HMGCR) variability, such as haplotype 7, which was shown to affect cholesterol synthesis and statin treatment outcome, diminishing possible neuroprotection associated with HMG-CoA reductase inhibitors administration. | Cholesterol | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 3 | We present possible statin effects on PD under the hypothesis that they may depend on the HMG-CoA reductase gene (HMGCR) variability, such as haplotype 7, which was shown to affect cholesterol synthesis and statin treatment outcome, diminishing possible neuroprotection associated with HMG-CoA reductase inhibitors administration. | Cholesterol | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |