Title : Low concentrations of 17β-estradiol exacerbate tamoxifen resistance in breast cancer treatment through membrane estrogen receptor-mediated signaling pathways.

Pub. Date : 2022 Mar

PMID : 34821461






1 Functional Relationships(s)
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1 Interestingly, E2 at environmental concentrations (0.1-10 nM) could activate the expression of both ERalpha36 and GPR30, and then stimulate the phosphorylation of ERK1/2 and Akt, resulting in cell growth promotion. Estradiol AKT serine/threonine kinase 1 Homo sapiens