Pub. Date : 2021 Nov 23
PMID : 34818536
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets. | Glutathione | pyruvate carboxylase | Homo sapiens |
| 2 | We find that pyruvate carboxylase is required for glutathione synthesis in islets and promotes their antioxidant capacity to counter inflammation and nitrosative stress. | Glutathione | pyruvate carboxylase | Homo sapiens |
| 3 | Loss- and gain-of-function studies indicate that pyruvate carboxylase is necessary and sufficient to mediate the metabolic input from glucose into glutathione synthesis and the oxidative stress response. | Glutathione | pyruvate carboxylase | Homo sapiens |
| 4 | Our findings reveal a direct interplay between glucose metabolism and glutathione biosynthesis via pyruvate carboxylase. | Glutathione | pyruvate carboxylase | Homo sapiens |