Pub. Date : 2021 Dec 9
PMID : 34818135
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Amantadine (N-methyl-D-aspartate (NMDA) receptor noncompetitive antagonist), NVP-AAM077 (GluN2A-containing NMDA receptor selective inhibitor) and Ro25-6981 (GluN2B-containing NMDA receptor selective inhibitor) also suppressed the Abeta25-35-induced PSD-95 tyrosine phosphorylation.Conclusion: These results suggest that Abeta oligomers induce the tyrosine phosphorylation of PSD-95 by SrcPTKs, which is mediated by the activation of GluN2A- and GluN2B-containing NMDA receptors.Section: Disease-Related Neuroscience. | Tyrosine | amyloid beta precursor protein | Rattus norvegicus |
| 2 | Amantadine (N-methyl-D-aspartate (NMDA) receptor noncompetitive antagonist), NVP-AAM077 (GluN2A-containing NMDA receptor selective inhibitor) and Ro25-6981 (GluN2B-containing NMDA receptor selective inhibitor) also suppressed the Abeta25-35-induced PSD-95 tyrosine phosphorylation.Conclusion: These results suggest that Abeta oligomers induce the tyrosine phosphorylation of PSD-95 by SrcPTKs, which is mediated by the activation of GluN2A- and GluN2B-containing NMDA receptors.Section: Disease-Related Neuroscience. | Tyrosine | amyloid beta precursor protein | Rattus norvegicus |