Pub. Date : 2021
PMID : 34803779
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genetic Modifiers of Oral Nicotine Consumption in Chrna5 Null Mutant Mice. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 5 | Mus musculus |
| 2 | Toward a better understanding of how loss of function of Chrna5 increases nicotine consumption, we have initiated efforts to identify genetic modifiers of Chrna5 deletion-dependent oral nicotine consumption in mice. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 5 | Mus musculus |
| 3 | Toward a better understanding of how loss of function of Chrna5 increases nicotine consumption, we have initiated efforts to identify genetic modifiers of Chrna5 deletion-dependent oral nicotine consumption in mice. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 5 | Mus musculus |
| 4 | As expected, nicotine consumption was significantly increased in Chrna5 KO mice relative to Chrna5 wildtype mice on a B6 background. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 5 | Mus musculus |
| 5 | Among the CSS homozygous for the Chrna5 KO allele, several exhibited altered nicotine consumption relative to B6 Chrna5 KO mice. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 5 | Mus musculus |
| 6 | In all cases nicotine consumption was reduced in the CSS Chrna5 KO mice relative to B6 Chrna5 KO mice and consumption in the CSS KO mice was indistinguishable from their wild type littermates. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 5 | Mus musculus |
| 7 | Nicotine consumption was also reduced in both Chrna5 KO and wildtype CSS mice possessing A/J chromosome 1 and increased in both KO and wild type chromosome 17 CSS relative to KO and wild type B6 mice. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 5 | Mus musculus |
| 8 | These results demonstrate the presence of several genetic modifiers of nicotine consumption in Chrna5 KO mice as well as identify loci that may affect nicotine consumption independent of Chrna5 genotype. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 5 | Mus musculus |
| 9 | Identification of the genes that underlie the altered nicotine consumption may provide novel insight into the mechanism through which Chrna5 deletion increases nicotine consumption and, more generally, a better appreciation of the neurobiology of nicotine intake. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 5 | Mus musculus |
| 10 | Identification of the genes that underlie the altered nicotine consumption may provide novel insight into the mechanism through which Chrna5 deletion increases nicotine consumption and, more generally, a better appreciation of the neurobiology of nicotine intake. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 5 | Mus musculus |