Pub. Date : 2021
PMID : 34803690
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Icariin Alleviates Wear Particle-Induced Periprosthetic Osteolysis via Down-Regulation of the Estrogen Receptor alpha-mediated NF-kappaB Signaling Pathway in Macrophages. | icariin | estrogen receptor 1 (alpha) | Mus musculus |
| 2 | The effects of icariin on wear particle-induced expression of proinflammatory factors, NF-kappaB signaling modulation, osteolysis, and estrogen receptor alpha (ERalpha) activation were evaluated in vitro and in vivo using bone marrow-derived macrophages and C57/BL6J mice, respectively. | icariin | estrogen receptor 1 (alpha) | Mus musculus |
| 3 | The effects of icariin on wear particle-induced expression of proinflammatory factors, NF-kappaB signaling modulation, osteolysis, and estrogen receptor alpha (ERalpha) activation were evaluated in vitro and in vivo using bone marrow-derived macrophages and C57/BL6J mice, respectively. | icariin | estrogen receptor 1 (alpha) | Mus musculus |
| 4 | A possible link between ERalpha and the protective effect of icariin was further studied using an ERalpha antagonist and the ERalpha-siRNA interference. | icariin | estrogen receptor 1 (alpha) | Mus musculus |
| 5 | A possible link between ERalpha and the protective effect of icariin was further studied using an ERalpha antagonist and the ERalpha-siRNA interference. | icariin | estrogen receptor 1 (alpha) | Mus musculus |
| 6 | The protective effects of icariin on CoCrMo particle-induced mouse calvarial osteolysis and on the inflammation response in BMDMs were reversed by ERalpha antagonist and by ERalpha-siRNA interference. | icariin | estrogen receptor 1 (alpha) | Mus musculus |
| 7 | The protective effects of icariin on CoCrMo particle-induced mouse calvarial osteolysis and on the inflammation response in BMDMs were reversed by ERalpha antagonist and by ERalpha-siRNA interference. | icariin | estrogen receptor 1 (alpha) | Mus musculus |
| 8 | In conclusion, icariin attenuates wear particle-induced inflammation and osteolysis via down-regulation of the ERalpha-mediated NF-kappaB signaling pathway in macrophages. | icariin | estrogen receptor 1 (alpha) | Mus musculus |