Title : Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration and bupropion-aided smoking cessation in African Americans? A moderated mediation analysis.

Pub. Date : 2022 Jun

PMID : 34791718






3 Functional Relationships(s)
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1 BACKGROUND AND AIMS: CYP2B6, a genetically variable enzyme, converts bupropion to its active metabolite hydroxybupropion. Bupropion cytochrome P450 family 2 subfamily B member 6 Homo sapiens
2 The aim of this study was to determine whether genetically normal (vs. reduced) CYP2B6 activity increases bupropion-aided cessation in African American smokers via higher hydroxybupropion concentration, and whether this differs by sex. Bupropion cytochrome P450 family 2 subfamily B member 6 Homo sapiens
3 CONCLUSIONS: In African American light-smokers with verified early bupropion use, genetically normal CYP2B6 activity appears to be indirectly associated with greater smoking cessation success in a relationship mediated by higher hydroxybupropion concentration. Bupropion cytochrome P450 family 2 subfamily B member 6 Homo sapiens