Title : Bacterial Lipopolysaccharide Augmented Malignant Transformation and Promoted the Stemness in Prostate Cancer Epithelial Cells.

Pub. Date : 2021

PMID : 34785925






2 Functional Relationships(s)
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1 Furthermore, blocking Stat3 signaling pathway by treatment with TSA and/or small molecule compound Stattic of an p-Stat3 inhibitor effectively abrogated LPS-induced tumorosphere forming with decrease of IL-6, IL-8 and stemness biomarkers CD44, SOX-2 expression. trichostatin A C-X-C motif chemokine ligand 8 Homo sapiens
2 TSA could prevent, at least in part, the LPS-induced malignant transformation by targeting p-Stat3/c-Myc signaling pathway and reducing inflammatory IL-6, IL-8. trichostatin A C-X-C motif chemokine ligand 8 Homo sapiens