Title : Inhibition of cathepsin K sensitizes oxaliplatin-induced apoptotic cell death by Bax upregulation through OTUB1-mediated p53 stabilization in vitro and in vivo.

Pub. Date : 2022 Jan

PMID : 34785775






3 Functional Relationships(s)
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1 Interestingly, ODN-induced p53 and Bax upregulation were modulated by the production of mitochondrial reactive oxygen species (ROS). Reactive Oxygen Species tumor protein p53 Homo sapiens
2 Interestingly, ODN-induced p53 and Bax upregulation were modulated by the production of mitochondrial reactive oxygen species (ROS). Reactive Oxygen Species tumor protein p53 Homo sapiens
3 Mitochondrial ROS scavengers prevented OTUB1-mediated p53 stabilization and Bax upregulation by ODN. Reactive Oxygen Species tumor protein p53 Homo sapiens