Pub. Date : 2022 Jan 30
PMID : 34780781
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Disulfide bonds play a critical role in the structure and function of the receptor-binding domain of the SARS-CoV-2 Spike antigen. | Disulfides | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 2 | The Spike proteins of coronaviruses, responsible for cell receptor binding and viral internalization, possess multiple and frequently conserved disulfide bonds raising the question about their role in these proteins. | Disulfides | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 3 | Here, we present a detailed structural and functional investigation of the disulfide bonds of the SARS-CoV-2 Spike receptor-binding domain (RBD). | Disulfides | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 4 | This flexibility is particularly prominent for the disulfide bond-containing surface loop (residues 456-490) that participates in the formation of the interaction surface with the Spike cell receptor ACE2. | Disulfides | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 5 | Our research demonstrates the mechanism by which the disulfide bonds contribute to the molecular structure of the RBD of the Spike protein, allowing the RBD to execute its viral function. | Disulfides | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |