Title : Oxidative stress as a critical factor might involve in intervertebral disc degeneration via regulating NOXs/FOXOs.

Pub. Date : 2021 Nov 9

PMID : 34772597






2 Functional Relationships(s)
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1 With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention. tert-Butylhydroperoxide forkhead box O1 Rattus norvegicus
2 With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention. tert-Butylhydroperoxide forkhead box O1 Rattus norvegicus