Title : Dexmedetomidine inhibits mitochondria damage and apoptosis of enteric glial cells in experimental intestinal ischemia/reperfusion injury via SIRT3-dependent PINK1/HDAC3/p53 pathway.

Pub. Date : 2021 Nov 12

PMID : 34772407






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Dexmedetomidine inhibits mitochondria damage and apoptosis of enteric glial cells in experimental intestinal ischemia/reperfusion injury via SIRT3-dependent PINK1/HDAC3/p53 pathway. Dexmedetomidine Wistar clone pR53P1 p53 pseudogene Rattus norvegicus
2 Further studies revealed that Dex provided protection against experimentally induced intestinal I/R injury in rats, while enhancing mitophagy, and suppressing apoptosis of EGCs through SIRT3-mediated PINK1/HDAC3/p53 pathway in the inflammation cell model. Dexmedetomidine Wistar clone pR53P1 p53 pseudogene Rattus norvegicus
3 CONCLUSION: Hence, these findings provide evidence supporting the protective effect of Dex against intestinal I/R injury and its underlying mechanism involving the SIRT3/PINK1/HDAC3/p53 axis. Dexmedetomidine Wistar clone pR53P1 p53 pseudogene Rattus norvegicus