Title : The Role of TP53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors.

Pub. Date : 2021 Oct 29

PMID : 34769213






5 Functional Relationships(s)
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1 The Role of TP53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors. Cisplatin tumor protein p53 Homo sapiens
2 The full knock-out of TP53 in 2102Ep and resistant NCCIT resulted in an increase in cisplatin resistance, suggesting a contributing role for P53, even in NCCIT, in which P53 had been reported to be non-functional. Cisplatin tumor protein p53 Homo sapiens
3 The full knock-out of TP53 in 2102Ep and resistant NCCIT resulted in an increase in cisplatin resistance, suggesting a contributing role for P53, even in NCCIT, in which P53 had been reported to be non-functional. Cisplatin tumor protein p53 Homo sapiens
4 The full knock-out of TP53 in 2102Ep and resistant NCCIT resulted in an increase in cisplatin resistance, suggesting a contributing role for P53, even in NCCIT, in which P53 had been reported to be non-functional. Cisplatin tumor protein p53 Homo sapiens
5 In conclusion, these results suggest that TP53 mutations contribute to the cisplatin-resistant phenotype of mediastinal GCTs and, therefore, are a potential candidate for targeted treatment. Cisplatin tumor protein p53 Homo sapiens