Pub. Date : 2022 Jan
PMID : 34752647
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Association of CYP2B6 genetic polymorphisms with bupropion and hydroxybupropion exposure: A systematic review and meta-analysis. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | INTRODUCTION: Bupropion is metabolized to its active metabolite, hydroxybupropion (HB), by the genetically polymorphic cytochrome P450 2B6 (CYP2B6) enzyme. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | INTRODUCTION: Bupropion is metabolized to its active metabolite, hydroxybupropion (HB), by the genetically polymorphic cytochrome P450 2B6 (CYP2B6) enzyme. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | OBJECTIVES: A systematic review and meta-analysis was conducted to quantify the association of bupropion and HB exposure with CYP2B6 variant alleles and genotype-defined metabolizer phenotypes. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | The ratio of means (RoM) between CYP2B6 genotype or genotype-defined phenotype groups for bupropion exposure was calculated for each study and combined in a meta-analysis. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 6 | The AUCs of HB and the active moiety (bupropion + HB) were significantly reduced in CYP2B6*6 carriers compared to the non-carriers (HB: RoM 0.77, 95% CI 0.71-0.83; active moiety: RoM 0.81, 95% CI 0.75-0.88). | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 7 | The findings of this study suggest opportunities to further study precision dosing strategies for bupropion therapy based on CYP2B6 genotype. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |