Pub. Date : 2021 Dec
PMID : 34740818
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In a target identification assay of anti-cancer compound using a modified DrugTargetSeqR strategy, mutation of TOP3B was detected in cancer cells acquired resistance to cinobufagin (CBG), a key compound of Huachansu that has been approved for cancer therapy in China. | cinobufagin | DNA topoisomerase III beta | Homo sapiens |
| 2 | In a target identification assay of anti-cancer compound using a modified DrugTargetSeqR strategy, mutation of TOP3B was detected in cancer cells acquired resistance to cinobufagin (CBG), a key compound of Huachansu that has been approved for cancer therapy in China. | cinobufagin | DNA topoisomerase III beta | Homo sapiens |
| 3 | We also demonstrated that CBG induced formation of stress granule, RNA-loop and asymmetric DNA damages in cancer cells, and all these phenotypes were significantly attenuated in TOP3B knockout cells. | cinobufagin | DNA topoisomerase III beta | Homo sapiens |
| 4 | Of note, examination of a panel of cancer cell lines revealed associations among cell growth inhibition and induction of DNA damage as well as TOP3B depletion upon CBG treatment. | cinobufagin | DNA topoisomerase III beta | Homo sapiens |