Title : Celastrol Inhibits the Proliferation and Induces Apoptosis of Colorectal Cancer Cells via Downregulating NF-κB/COX-2 Signaling Pathways.

Pub. Date : 2022

PMID : 34732120






1 Functional Relationships(s)
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1 RESULTS: Celastrol effectively inhibited CRC cell proliferation by activating caspase-dependent cell apoptosis and facilitating G1 cell cycle arrest in a dose-dependent manner, as well as cell migration and invasion by downregulating the MMP2 and MMP9. celastrol matrix metallopeptidase 2 Homo sapiens