Title : Hexokinases II-mediated glycolysis governs susceptibility to crizotinib in ALK-positive non-small cell lung cancer.

Pub. Date : 2021 Dec

PMID : 34729938






2 Functional Relationships(s)
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1 2DG sensitization crizotinib might be associated with the inhibition of HK2-mediated glycolysis and P-ALK/AKT/mTOR signaling pathway in H3122 and H2228 cells. Deoxyglucose hexokinase 2 Homo sapiens
2 2DG may sensitize ALK+ NSCLC to crizotinib via suppression of HK2-mediated glycolysis and the AKT/mTOR signaling pathway. Deoxyglucose hexokinase 2 Homo sapiens