Title : Endothelial TrkB receptor activation controls vascular tone of rat middle cerebral artery.

Pub. Date : 2021 Dec

PMID : 34728386






2 Functional Relationships(s)
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1 Exposure of MCA with the TrkB agonist LM22A-4 that increased expression of TrkB receptors phosphorylated at tyrosine 816 induced relaxation of preconstricted MCA (EC50 6.7 x 10-8 mol/L) as efficiently than acetylcholine (EC50 5.3 x 10-8 mol/L). Tyrosine neurotrophic receptor tyrosine kinase 2 Rattus norvegicus
2 Exposure of MCA with the TrkB agonist LM22A-4 that increased expression of TrkB receptors phosphorylated at tyrosine 816 induced relaxation of preconstricted MCA (EC50 6.7 x 10-8 mol/L) as efficiently than acetylcholine (EC50 5.3 x 10-8 mol/L). Tyrosine neurotrophic receptor tyrosine kinase 2 Rattus norvegicus