Pub. Date : 2021 Nov 1
PMID : 34725432
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cancer linked isocitrate dehydrogenase (IDH) 1 variants, notably R132H IDH1, manifest a "gain-of-function" to reduce 2-oxoglutarate to 2-hydroxyglutarate. | Ketoglutaric Acids | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | The isocitrate-Mg2+ complex is the preferred wt IDH1 substrate; with R132H IDH1, separate and weaker binding of 2-oxoglutarate and Mg2+ is preferred. | Ketoglutaric Acids | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | The isocitrate-Mg2+ complex is the preferred wt IDH1 substrate; with R132H IDH1, separate and weaker binding of 2-oxoglutarate and Mg2+ is preferred. | Ketoglutaric Acids | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |