Pub. Date : 2021 Dec
PMID : 34724097
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By silencing Akt isoforms individually and in pairs, in Neuro-2a and HT22 cells we observed that, in insulin-sensitive condition, Akt isoforms differentially reduced activation of AS160 and glucose uptake with Akt2 playing the major role. | Glucose | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | By silencing Akt isoforms individually and in pairs, in Neuro-2a and HT22 cells we observed that, in insulin-sensitive condition, Akt isoforms differentially reduced activation of AS160 and glucose uptake with Akt2 playing the major role. | Glucose | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Over-expression of individual isoforms in insulin-sensitive and resistant cells differentially reversed AS160 phosphorylation with concomitant reversal in glucose uptake indicating a compensatory role of Akt isoforms in controlling neuronal insulin signaling. | Glucose | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | Post-insulin stimulation Akt2 translocated to the membrane the most followed by Akt3 and Akt1, decreasing glucose uptake in the similar order in insulin-sensitive cells. | Glucose | thymoma viral proto-oncogene 1 | Mus musculus |
| 5 | Thus, isoforms play parallel with predominant role by Akt2, and compensatory yet novel role by Akt1 and Akt3 to regulate neuronal insulin signaling, glucose uptake, and insulin-resistance. | Glucose | thymoma viral proto-oncogene 1 | Mus musculus |