Pub. Date : 2022 Feb
PMID : 34719075
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dipeptidyl peptidase-8 induces Sorafenib resistance via binding with c-Rel to mediate NF-kappaB signaling in hepatocellular carcinoma. | Sorafenib | dipeptidyl peptidase 8 | Homo sapiens |
| 2 | The present study aimed to determine the involvement of dipeptidyl peptidase-8 (DPP8) in Sorafenib resistance. | Sorafenib | dipeptidyl peptidase 8 | Homo sapiens |
| 3 | The present study aimed to determine the involvement of dipeptidyl peptidase-8 (DPP8) in Sorafenib resistance. | Sorafenib | dipeptidyl peptidase 8 | Homo sapiens |
| 4 | The effect of DPP8 on Sorafenib resistance was examined using terminal deoxynulceotidyl transferase nick-end-labeling (TUNEL), colony formation, flow cytometry, luciferase reporter, immunofluorescence, and immunoprecipitation (IP) assays. | Sorafenib | dipeptidyl peptidase 8 | Homo sapiens |
| 5 | Downregulation of DPP8 substantially promoted the sensitivity of HCC cells to Sorafenib. | Sorafenib | dipeptidyl peptidase 8 | Homo sapiens |
| 6 | Finally, a drug combination of Sorafenib and Val-boroPro induced higher mortality of HCC cells than Sorafenib alone in DPP8-upregulated cells. | Sorafenib | dipeptidyl peptidase 8 | Homo sapiens |