Pub. Date : 2021 Dec
PMID : 34717078
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Conflicting results have been reported regarding the effect of metformin on adiponectin levels in women with polycystic ovary syndrome (PCOS). | Metformin | adiponectin, C1Q and collagen domain containing | Homo sapiens |
| 2 | This meta-analysis reviewed all studies comparing adiponectin levels before and after metformin treatment in PCOS women. | Metformin | adiponectin, C1Q and collagen domain containing | Homo sapiens |
| 3 | RESULTS: Metformin treatment was associated with significantly increased serum adiponectin concentrations (10 studies, random-effects SMD (95% CI) -0.58 (-1.03, -0.13); I2 = 86%; P = 0.01). | Metformin | adiponectin, C1Q and collagen domain containing | Homo sapiens |
| 4 | CONCLUSION: Following metformin administration, serum adiponectin concentrations of PCOS women were found to be significantly increased, accompanied by a significant improvement in other indicators. | Metformin | adiponectin, C1Q and collagen domain containing | Homo sapiens |