Title : Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors.

Pub. Date : 2022 Mar 17

PMID : 34715056






1 Functional Relationships(s)
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1 Disrupting mitochondrial metabolism via chemical inhibition of electron transport, deletion of the malate-aspartate shuttle component GOT1, or endogenous mutations in tricarboxylic acid cycle enzymes, causes synthetic lethality with KL-11743. Aspartic Acid glutamic-oxaloacetic transaminase 1 Homo sapiens