Pub. Date : 2022 Feb
PMID : 34713897
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sodium-glucose co-transporter 2 inhibitors (SGLT2-Is) have emerged as a promising class of antidiabetic drugs with cardioprotective and renoprotective effects in patients with type 2 diabetes (T2D). | Glucose | solute carrier family 5 member 2 | Homo sapiens |
| 2 | The sodium-glucose co-transporters 1 and 2 (SGLT 1 and SGLT2) located in the renal proximal tubules are responsible for glucose reabsorption from the glomerular filtrate back into the systemic circulation. | Glucose | solute carrier family 5 member 2 | Homo sapiens |
| 3 | Inhibition of SGLT2, which accounts for about 90% of the glucose reabsorption, leads to a significant reduction in blood glucose levels and a concomitant increase in the urinary excretion of glucose (glycosuria). | Glucose | solute carrier family 5 member 2 | Homo sapiens |
| 4 | Inhibition of SGLT2, which accounts for about 90% of the glucose reabsorption, leads to a significant reduction in blood glucose levels and a concomitant increase in the urinary excretion of glucose (glycosuria). | Glucose | solute carrier family 5 member 2 | Homo sapiens |