Title : Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia.

Pub. Date : 2022 Mar 1

PMID : 34711640






1 Functional Relationships(s)
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1 ETP-ALLs showed increased biosynthesis of phospholipids and sphingolipids, and were specifically sensitive to inhibition of 3-hydroxy-3-methylglutaryl-CoA Reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathway. Sphingolipids 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens