Title : CYP2J2-produced epoxyeicosatrienoic acids contribute to the ferroptosis resistance of pancreatic ductal adenocarcinoma in a PPARγ-dependent manner.

Pub. Date : 2021 Sept 28

PMID : 34707002






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cytochrome P450 2J2 (CYP2J2) is the main enzyme which mediates arachidonic acid to produce epoxyeicosatrienoic acids (EETs) in human tissues. eets cytochrome P450 family 2 subfamily J member 2 Homo sapiens
2 Cytochrome P450 2J2 (CYP2J2) is the main enzyme which mediates arachidonic acid to produce epoxyeicosatrienoic acids (EETs) in human tissues. eets cytochrome P450 family 2 subfamily J member 2 Homo sapiens
3 It has been reported that EETs involve in the development of cancer, while the roles of EETs in PDAC and ferroptosis remain unclear.This study aims to explore the effect of CYP2J2/EETs on ferroptosis of human pancreatic ductal adenocarcinoma cells PANC-1 cells and the underlying mechanisms. eets cytochrome P450 family 2 subfamily J member 2 Homo sapiens