Pub. Date : 2021 Oct 6
PMID : 34703544
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo. | Platinum | albumin | Homo sapiens |
2 | KP2156 forms very stable albumin adducts in the bloodstream resulting in a superior pharmacological profile, such as distinctly prolonged terminal excretion half-life and enhanced effective platinum dose (measured by ICP-MS). | Platinum | albumin | Homo sapiens |
3 | Summarizing, albumin-binding of platinum(iv) complexes potently enhances the efficacy of oxaliplatin therapy and should be further developed towards clinical phase I trials. | Platinum | albumin | Homo sapiens |