Title : Inhaled gene therapy of preclinical muco-obstructive lung diseases by nanoparticles capable of breaching the airway mucus barrier.

Pub. Date : 2021 Oct 25

PMID : 34697091






1 Functional Relationships(s)
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1 A plasmid designed to silence epithelial sodium channel (ENaC) hyperactivity, which causes airway surface dehydration and mucus stasis, was intratracheally administered via DNA-MPP to evaluate therapeutic effects in vivo with or without pretreatment with hypertonic saline, a clinically used mucus-rehydrating agent. Sodium sodium channel, nonvoltage-gated 1 alpha Mus musculus