Title : Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naïve and primed pluripotent stem cells.

Pub. Date : 2021 Nov

PMID : 34688658






1 Functional Relationships(s)
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1 Mechanistically, we demonstrate that USP13 physically interacts with, deubiquitinates, and stabilizes serine/threonine kinase Raf1 and thereby sustains Raf1 protein at the posttranslational level to activate the FGF/MEK/ERK pro-differentiation signaling pathway in naive mouse ESCs. Serine v-raf-leukemia viral oncogene 1 Mus musculus