Title : Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model.

Pub. Date : 2021 Oct 22

PMID : 34686711






1 Functional Relationships(s)
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1 We have previously shown that systemic GCS inhibition reduced GlcCer and glucosylsphingosine (GlcSph) accumulation, slowed alpha-synuclein buildup in the hippocampus, and improved cognitive deficits. Glucosylceramides UDP-glucose ceramide glucosyltransferase Mus musculus