Pub. Date : 2022 Apr
PMID : 34686523
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The G-protein coupled receptor TGR5 regulates the bile acid induced alterations of intermediary metabolism, while the nuclear receptor FXR regulates bile acid synthesis and homeostasis. | Bile Acids and Salts | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 2 | However, this review indicates that unidentified factors in addition to FXR must exist to aid in the regulation of bile acid synthesis and homeostasis. | Bile Acids and Salts | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 3 | Significance Statement This review captures the present understanding of bile acid synthesis, the role of bile acid transporters in the enterohepatic circulation of bile acids, the role of the nuclear receptor FXR on the regulation of bile acid synthesis and bile acid transporters, and the importance of bile acids in activating GPCR signaling via TGR5 to modify intermediary metabolism. | Bile Acids and Salts | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 4 | Significance Statement This review captures the present understanding of bile acid synthesis, the role of bile acid transporters in the enterohepatic circulation of bile acids, the role of the nuclear receptor FXR on the regulation of bile acid synthesis and bile acid transporters, and the importance of bile acids in activating GPCR signaling via TGR5 to modify intermediary metabolism. | Bile Acids and Salts | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |