Pub. Date : 2021 Oct 15
PMID : 34682865
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Diosmetin Induces Modulation of Igf-1 and Il-6 Levels to Alter Rictor-Akt-PKCalpha Cascade in Inhibition of Prostate Cancer. | diosmetin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Subsequently, it was found that diosmetin, a natural plant aglycone, had the potential to modulate the downstream signaling cascade of Rictor/AKT/PKCalpha to inhibit the progression of prostate cancer. | diosmetin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Treatment of LNCaP and PC-3 cells with diosmetin inhibited the phosphorylation of Rictor (Thr-1135), AKT (Ser-473) and PKCalpha (Ser-657) in a dose-dependent manner. | diosmetin | AKT serine/threonine kinase 1 | Homo sapiens |