Pub. Date : 2021 Oct 15
PMID : 34681815
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytosolic Phospholipase A2 Is Required for Fexofenadine"s Therapeutic Effects against Inflammatory Bowel Disease in Mice. | fexofenadine | phospholipase A2, group IVA (cytosolic, calcium-dependent) | Mus musculus |
| 2 | Additionally, cytosolic phospholipase A2 (cPLA2) was isolated as a binding target of fexofenadine, and fexofenadine-mediated anti-TNF activity relied on cPLA2 in vitro. | fexofenadine | phospholipase A2, group IVA (cytosolic, calcium-dependent) | Mus musculus |
| 3 | Additionally, cytosolic phospholipase A2 (cPLA2) was isolated as a binding target of fexofenadine, and fexofenadine-mediated anti-TNF activity relied on cPLA2 in vitro. | fexofenadine | phospholipase A2, group IVA (cytosolic, calcium-dependent) | Mus musculus |
| 4 | Additionally, cytosolic phospholipase A2 (cPLA2) was isolated as a binding target of fexofenadine, and fexofenadine-mediated anti-TNF activity relied on cPLA2 in vitro. | fexofenadine | phospholipase A2, group IVA (cytosolic, calcium-dependent) | Mus musculus |
| 5 | Additionally, cytosolic phospholipase A2 (cPLA2) was isolated as a binding target of fexofenadine, and fexofenadine-mediated anti-TNF activity relied on cPLA2 in vitro. | fexofenadine | phospholipase A2, group IVA (cytosolic, calcium-dependent) | Mus musculus |
| 6 | Additionally, cytosolic phospholipase A2 (cPLA2) was isolated as a binding target of fexofenadine, and fexofenadine-mediated anti-TNF activity relied on cPLA2 in vitro. | fexofenadine | phospholipase A2, group IVA (cytosolic, calcium-dependent) | Mus musculus |
| 7 | The objective of this study is to determine whether fexofenadine is therapeutic against chemically-induced murine IBD model and whether cPLA2 and/or histamine H1 receptor is important for fexofenadine"s anti-inflammatory activity in vivo by leveraging various genetically modified mice and chemically induced murine IBD models. | fexofenadine | phospholipase A2, group IVA (cytosolic, calcium-dependent) | Mus musculus |
| 8 | Intriguingly, Fexofenadine-mediated protective effects against IBD were lost in cPLA2 deficient mice but not in histamine H1 receptor-deficient mice. | fexofenadine | phospholipase A2, group IVA (cytosolic, calcium-dependent) | Mus musculus |
| 9 | Collectively, these findings demonstrate the therapeutic effects of over-the-counter drug Fexofenadine in treating DSS-induced IBD murine and provide first in vivo evidence showing that cPLA2 is required for fexofenadine"s therapeutic effects in murine IBD model and probably other inflammatory and autoimmune diseases as well. | fexofenadine | phospholipase A2, group IVA (cytosolic, calcium-dependent) | Mus musculus |