Title : FRI-1 Is an Anti-Cancer Isoquinolinequinone That Inhibits the Mitochondrial Bioenergetics and Blocks Metabolic Shifts by Redox Disruption in Breast Cancer Cells.

Pub. Date : 2021 Oct 14

PMID : 34679752






2 Functional Relationships(s)
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1 Remarkably, alpha-ketoglutarate and lipoic acid supplementation reversed and promoted, respectively, the FRI-1-induced apoptosis, suggesting that mitochondrial redox disruption affects 2-oxoglutarate dehydrogenase (OGDH) activity, and this is involved in their anticancer mechanism. Ketoglutaric Acids oxoglutarate dehydrogenase Homo sapiens
2 Remarkably, alpha-ketoglutarate and lipoic acid supplementation reversed and promoted, respectively, the FRI-1-induced apoptosis, suggesting that mitochondrial redox disruption affects 2-oxoglutarate dehydrogenase (OGDH) activity, and this is involved in their anticancer mechanism. Ketoglutaric Acids oxoglutarate dehydrogenase Homo sapiens