Title : Hyperprogression of a mismatch repair-deficient colon cancer in a humanized mouse model following administration of immune checkpoint inhibitor pembrolizumab.

Pub. Date : 2021 Oct 12

PMID : 34676046






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using human cytotoxic T-cell line TALL-104 injected intraperitoneally into immunodeficient NCRU-nude athymic mice bearing mismatch repair-deficient (MMR-d) human colon carcinoma HCT116 p53-null (but not wild-type p53) tumor xenograft, we observed accelerated tumor growth after PD-1 blockade with pembrolizumab administration. tall-104 spermatogenesis associated 2 Homo sapiens