Pub. Date : 2021 Oct 21
PMID : 34675006
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we demonstrate that hepatic p38 activation by MKK6 overexpression in the liver of mice induces severe liver steatosis, reduces fat mass, and elevates circulating fatty acid levels in a hepatic p38alpha- and FGF21-dependent manner. | Fatty Acids | mitogen-activated protein kinase 14 | Mus musculus |
| 2 | Here, we demonstrate that hepatic p38 activation by MKK6 overexpression in the liver of mice induces severe liver steatosis, reduces fat mass, and elevates circulating fatty acid levels in a hepatic p38alpha- and FGF21-dependent manner. | Fatty Acids | mitogen-activated protein kinase 14 | Mus musculus |
| 3 | Mechanistically, through increasing the FGF21 production from liver, hepatic p38 activation increases the influx of fatty acids from adipose tissue to liver, leading to hepatic ectopic lipid accumulation and insulin resistance. | Fatty Acids | mitogen-activated protein kinase 14 | Mus musculus |