Pub. Date : 2021 Oct 18
PMID : 34663387
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Besides, the mRNA level of growth-associated protein 43 (GAP43) in OGD neurons with Scu treatment was detected by quantitative real-time polymerase chain reaction (qRT-PCR). | scutellarin | growth associated protein 43 | Rattus norvegicus |
| 2 | Besides, the mRNA level of growth-associated protein 43 (GAP43) in OGD neurons with Scu treatment was detected by quantitative real-time polymerase chain reaction (qRT-PCR). | scutellarin | growth associated protein 43 | Rattus norvegicus |
| 3 | To further verify the role of GAP43 in Scu treatment, GAP43 siRNA and knockout were applied in vitro and in vivo. | scutellarin | growth associated protein 43 | Rattus norvegicus |
| 4 | And the expression of GAP43 was downregulated after OGD, but reversed by Scu administration. | scutellarin | growth associated protein 43 | Rattus norvegicus |
| 5 | CONCLUSIONS: Collectively, our findings revealed Scu treatment attenuated long-term neurological impairments after HI by suppressing neuronal death and enhancing neurite elongation through GAP43-dependent pathway. | scutellarin | growth associated protein 43 | Rattus norvegicus |