Title : Sodium Acetate Inhibit TGF-β1-Induced Activation of Hepatic Stellate Cells by Restoring AMPK or c-Jun Signaling.

Pub. Date : 2021

PMID : 34660662






3 Functional Relationships(s)
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1 The results of phosphokinase array kit and Western blot indicated that NaA increased the AMP-activated protein kinase (AMPK) activation and reduced the phosphorylation of c-Jun in cultured LX2 cells, and siRNA-peroxisome proliferator-activated receptor (PPAR) -gamma abolished the inhibitory effects of NaA against TGF-beta1-induced LX2 cell activation. 1-naphthaleneacetic acid Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 The results of phosphokinase array kit and Western blot indicated that NaA increased the AMP-activated protein kinase (AMPK) activation and reduced the phosphorylation of c-Jun in cultured LX2 cells, and siRNA-peroxisome proliferator-activated receptor (PPAR) -gamma abolished the inhibitory effects of NaA against TGF-beta1-induced LX2 cell activation. 1-naphthaleneacetic acid Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 In conclusion, this study showed that NaA inhibited LX2 cell activation by activating the AMPK/PPARgamma and blocking the c-Jun signaling pathways. 1-naphthaleneacetic acid Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens