Title : The MID1 Protein: A Promising Therapeutic Target in Huntington's Disease.

Pub. Date : 2021

PMID : 34659371






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Huntington"s disease (HD) is caused by an expansion mutation of a CAG repeat in exon 1 of the huntingtin (HTT) gene, that encodes an expanded polyglutamine tract in the HTT protein. polyglutamine huntingtin Homo sapiens
2 Huntington"s disease (HD) is caused by an expansion mutation of a CAG repeat in exon 1 of the huntingtin (HTT) gene, that encodes an expanded polyglutamine tract in the HTT protein. polyglutamine huntingtin Homo sapiens
3 Huntington"s disease (HD) is caused by an expansion mutation of a CAG repeat in exon 1 of the huntingtin (HTT) gene, that encodes an expanded polyglutamine tract in the HTT protein. polyglutamine huntingtin Homo sapiens
4 Since MID1 is a translation regulator, association of the MID1 complex stimulates translation of mutant HTT mRNA, resulting in an overproduction of polyglutamine protein. polyglutamine huntingtin Homo sapiens