Title : Generation of Caco-2 cells stably expressing CYP3A4·POR·UGT1A1 and CYP3A4·POR·UGT1A1*6 using a PITCh system.

Pub. Date : 2022 Feb

PMID : 34654938






1 Functional Relationships(s)
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1 Patients with genotype UGT1A1*6 (exon 1, 211G > A) treated with the antineoplastic drug SN-38 have been reported to exhibit decreased glucuronide conjugation and increased incidence of intestinal toxicity and its severe side effects, including severe diarrhea. Glucuronides UDP glucuronosyltransferase family 1 member A1 Homo sapiens